A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp

Murtihapsari, Amir M. Suruwaky, Kadarusman, Dikdik Kurnia, Tati Herlina, Unang Supratman

A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp

Murtihapsari, Amir M. Suruwaky, Kadarusman, Dikdik Kurnia, Tati Herlina, Unang Supratman

URI: http://repository.unipa.ac.id:8080/xmlui/handle/123456789/1075

Date: 2018-05-30

Abstract:

A new antiplasmodial compound, 2-(3H-diazirine-3-yl)benzaldehyde (1), has been isolated from the Papuan marine sponge Xestospongia sp. The structure elucidation of compound 1 was determined by spectroscopic evidences including UV, IR, MS, 1D and 2D-NMR analysis. Compound 1 showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 value of 1.08  10-6M.

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