Abstract:
The effectiveness of atherogenic diet in raising plasma cholesterol level of cynomolgus macaques (Macaca fascicularis) can be predicted for population, but not for individuals.This study aimed to evaluate the individual plasma cholesterol of cynomolgus macaques in response to IPB-1 atherogenic diet. The animals under study were 22 adult malemonkeys from the animal facility of Primate Research Center Bogor Agricultural University (PSSP IPB). All animals were intervened with the IPB-1 atherogenic diet for three months and individual plasma cholesterol wasevaluated in a monthly basis.The results showed that the monkeys’ plasma cholesterol had increased significantly (P <0.05) after one month of intervention period and the increases were very significantly different (P <0.01) after three months. Individually, increases in plasma cholesterol varied among animals. Based on these variations, 2 animals were categorised as ypo-response, 18 animals as hyper-response and 2 animals as extreme.This study showed the variation of individual plasma cholesterol of cynomolgus macaques in response tothe IPB-1 atherogenic diet so that the animals might be selected based on the their responsiveness.
