Abstract:
Low-density lipoprotein receptors (LDL-R) play a role in transporting plasma cholesterol into cells. This protein is encoded by the LDLR gene that contains the 3'untranslated region (3'UTR). 3'UTR is known as an important regulatory element to the precision of expression in many genes. The genetic variation of the 3'UTR region in some tribal populations indicates that this area has a high diversity. So it can be used to study the evolution of genetic diversity. A total of 9 individuals from Papua from
different districts were analyzed for their 3'UTR area. The results of this study indicate that the variation of nucleotides obtained ranges from 0 to 3 nucleotides with an average of 0.0611 nucleotides and nucleotide diversity (π) of 0.00105 nucleotides. In addition, two SNPs were identified in positions *315 and *540 consisting of two general haplotypes (CG and GG) and one special haplotype (CA) with a haplotype diversity of 0.556 ± 0.165. The results of this study can be concluded that the 3'UTR area has a low genetic diversity with a small number of samples.
